No-carrier-added labeling of the neuroprotective Ebselen with selenium-73 and selenium-75.
نویسندگان
چکیده
Selenium-73 is a positron emitting non-standard radionuclide, which is suitable for positron emission tomography. A copper-catalyzed reaction allowed no-carrier-added labeling of the anti-inflammatory seleno-organic compound Ebselen with (73) Se and (75) Se under addition of sulfur carrier in a one-step reaction. The new authentically labeled radioselenium molecule is thus available for preclinical evaluation and positron emission tomography studies.
منابع مشابه
Simultaneous production and quality control of 73Se and 75Se radioisotopes in a 30 MeV cyclotron
Background : Selenium-73 (T 1/2 =7.1h) and Selenium-75 (T 1/2 =119.8d) are useful radioisotopes in many research fields. The wide ranges of applications of these radioisotopes arose great interest for their production. Simultaneous production of 73 Se and 75 Se is more cost-effective and less time-consuming. Materials and Methods : 73 As (p, 3n) 73 Se and 75 As (p,n) 75 Se reactions were determ...
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ورودعنوان ژورنال:
- Journal of labelled compounds & radiopharmaceuticals
دوره 58 3 شماره
صفحات -
تاریخ انتشار 2015